The ENGAGE Trial (Status: Ongoing)
Through the ENGAGE trial, our research team has collaborated with consumers and representatives from the Leukaemia Foundation to design a 12-week multidisciplinary survivorship intervention (ENGAGE Intervention) that aims to improve health related quality of life in patients who have recently completed curative intent treatment for lymphoma. This intervention includes (1) a tailored survivorship care plan, evidence-based education incorporating self-management strategies, and referrals to specialised services; (2) a shared-care model that utilises the expertise of hospital specialists (i.e., haematologists, specialist cancer nurses) and GPs. This model enables collaboration with primary care professionals (GPs) to deliver patient-centred care – the hallmark of high-quality care and a well-functioning health system. Telehealth technologies will also be used to ensure people in regional, rural and remote areas can receive the intervention. While nationally endorsed models of survivorship exist, these models are broad and specify generalised elements of survivorship only. Few RCTs exist that have tested the use of innovative strategies to promote a shared-care model in any survivorship setting, and no studies exist that focus on the specific needs of the lymphoma population. We are currently conducting a pilot RCT, which will ultimately inform the world’s first pragmatic, phase III RCT to evaluate the effectiveness and cost-effectiveness of a structured post-treatment survivorship intervention for patients with lymphoma. For more information, please contact Professor Raymond Chan.
QCCS Team Members
QCCS Co-Chair and Professor of Nursing
Doctor of Philosophy (Queensland University of Technology), Master of Applied Science (Research) (Queensland University of Technology), Bachelor of Nursing (Queensland University of Technology)
Dr Raymond Chan is Professor of Cancer Nursing, Princess Alexandra Hospital and Queensland University of Technology. He currently holds a NHMRC Health Professional Research Fellowship. He is currently the President for the Cancer Nurses Society of Australia (CNSA), the peak professional body representing over 1,200 cancer nurses across Australia. To date, he has attracted over 6 million (AUD) of research project grants as a chief investigator (> $1 Million as CIA) to undertake research in supportive cancer care. Dr Chan is a chief investigator for 4 current NHMRC project grants and has published over 80 peer-reviewed articles. He is also the Associate Editor for Cancer Nursing: An International for Cancer Care (Ranking 8/108 in Nursing).
Recent funded project highlights include:
- (2017-2020): A sequential multiple assignment randomised trial (SMART) of nursing interventions to reduce pain associated with chemotherapy induced peripheral neuropathy. NHMRC (CID)
- (2016-2019): Peripherally InSerted Central catheter Securement: the PISCES Trial. NHMRC (CIC)
- (2014-2017): Development and evaluation of a nurse-led, tailored self-management behavioural intervention for managing distressing symptoms in patients with advanced cancer (The SM2 Study). RBWH Foundation and NHMRC (CIA)
- (2014-2015): Younger women’s wellness after cancer program. RBWH Foundation (CID)
- (2014): Central venous Access device SeCurement And Dressing Effectiveness in Cancer Care: The CASCADE Trial. RBWH Foundation (CIA)
- (2013-2016): Improving quality of life in high-risk cancer populations: a randomised trial of a structured intervention for head and neck cancer survivors. NHMRC (CIJ)
- (2012-2013): A double-blind randomised controlled trial of Moogoo Udder Cream® versus aqueous cream for managing radiation-induced skin reactions in patients with cancer. RBWH Foundation; Office of Health and Medical Research; Cancer Nurses Society of Australia; Moogoo Skincare
- (2011-2014): The RSVP Trial: Replacement of Intravascular device administration sets after Standard Versus Prolonged use. NHMRC and RBWH Foundation (CIG)
- (2010): Self-management associated with fatigue in patients with advanced cancer. RBWH Foundation, Queensland Nursing Council, Royal College of Nursing Australia (CIA)
Recent QCCS Project
- The effects of bundled interventions on clinical practice for fertility preservation amongst young cancer patients
Prof Geoff Mitchell
Professor of Medicine (General Practice), UQ
- Bachelor of Medicine/Surgery (Graduate Entry), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Geoff. Mitchell is Professor of General Practice and Palliative Care, and head of the MBBS Program at Ipswich.
Professor Mitchell’s main research interest is in the role of General Practitioners in palliative care. His other research interests are in GP management of chronic and complex conditions including Pain and Attention Deficit Hyperactivity Disorder, and in quality issues in General Practice. He has authored over 140 refereed journal articles, as well as numerous book chapters and reports in these and other areas of clinical general practice. He was awarded his PhD in May 2005.
He was involved in the development of a Hospice and a regional palliative care network in Ipswich, Queensland, and was the inaugural Director of the Centre for Palliative Care Research and Education. In 2008, he authored a book entitled “Palliative care: a patient centered method”. He has co-authored clinical handbooks of Palliative Care entitled “The Blue Book of Palliative Care”, and “Therapeutics Guidelines: Palliative care”, and a national report into the palliative care education and support needs of GPs in palliative care. He maintains a clinical general practice in Ipswich, Queensland. He also heads a research program utilising n-of-1 trial design for the evaluation of treatments in patient groups with small numbers, or people who are difficult to retain in more standard treatment trials.
Interest in the general practice and community management of palliative care patients. Also in the development of clinical evidence in palliative care.
Interest in the GP diagnosis and management of ADHD. Interest in the development of strategies to enhance the abilitiy of GPs to manage the condition successfully. These include a diagnostic aide, and the use of single patient technology to aide in evidence based management of the condition.
Most of Professor Mitchell’s impact is in influencing the conduct of palliative care in the community. This is an important area of research, given that the population is ageing, and many more people will come to the end of their lives in the medium term than is the case now. The community needs to be prepared for this eventuality, by ensuring that appropriate skills are held by all community based practitioners, and that high quality coordination between specialists and generalists is available to those who need it. this has involved knowledge dissemination initiatives such as national symptom guideline development, and gathering and implementing high quality evidence of community initiatives within end of life care.
He has an international reputation as a speaker in this area. He initiated an international group of practitioners to promote this research and policy agenda – the International Primary Palliative Care Network. He has had input into major policy initiatives at local, state and national levels.
Prof Jane Turner
Professor of Medicine (Psychiatry) Psycho-Oncologist, UQ
- Doctor of Philosophy, The University of Queensland
- FRANZCP, Royal Australian and New Zealand College of Psychiatrists
- MBBS, The University of Queensland
I have worked for over 20 years in the field of Psycho-Oncology as a psychiatrist providing treatment for patients with cancer and their families, and developing a program of research focused on interventions in areas of clinical need, and translational research examining sustainable models of service delivery.
Psycho-Oncology encompasses attention to the psychological, emotional and social needs of people with cancer and their families or carers. It encompasses attention to spiritual and cultural concerns, across all phases of the cancer experience from diagnosis, through treatment, survivorship or advanced diseases. It is a relatively new discipline. The International Psycho-Oncology Society was established in 1984. As such, much of the research in this field has been descriptive and it is only in recent years that robust trials of interventions have become more common. involves attention to the psychological, emotional and social needs of people with cancer and their family or carers. ath.
My research in Psycho-Oncology relates to three core themes which draw on both my clinical and educational expertise:
1. Promotion of wellness following completion of active cancer treatment:
Current RCTs are:
- Improving quality of life in high-risk cancer populations: a randomised trial of a structured intervention for head and neck cancer survivors (Turner, Yates, Kenny, Gordon, Burmeister, Thomson, Hughes, McCarthy, Perry, Chan)
- The women’s wellness after cancer program: a national multisite RCT of an E-Health enabled lifestyle modification intervention to improve the health and wellness of women after cancer treatment (Anderson, McCarthy, Yates, Turner, Monterosso, Krishnasamy, White, Hall, Tjondronegoro)
- Evaluation of a psychological and educational intervention for fear of cancer recurrence: A clustered randomised controlled trial (Butow, Thewes, Turner, Gilchrist, Beith, Girgis, Sharpe, Bell, Mihalopoulos).
- Coping Together: A randomised controlled trial of a self-directed coping skills intervention for patients with cancer and their partners (Girgis, Lambert, Turner, McElduff, Kayser, Mihalopoulos).
- Finding My Way: A randomised controlled trial evaluating an internet self-help program for cancer-related distress (Beatty, Koczwara, Wade, Turner, Butow, Knott, Lambert, Milne, Wootten, De Bono, Katris)
Completed studies include: i) a pilot study of an exercise intervention for women after completion of chemotherapy for breast cancer (Turner, Hayes, Reul-Hirche); ii) RCT of exercise in women with Lymphoedema secondary to treatment for breast cancer (Hayes, Reul-Hirche, Turner), iii) RCT examining promotion of wellness through cancer helplines (Chambers, Occhipinti, Turner, Carter, Dunn).
2. The emotional dimensions of cancer for patients and dependent children:
Initial work exploring the emotional impact of the diagnosis of advanced breast cancer (Turner, Kelly, Swanson, Allison, Wetzig) identified key areas of unmet need relating to concerns of parents and their response to their children.
This provided the impetus for a pilot study in which an educational intervention was developed to enhance the capacity of oncology nurses to provide supportive care for parents with advanced cancer (Turner, Clavarino, Butow, Yates, Hargraves, O’Connor, Hausmann).
Collaborations in the area of advanced cancer include a multi-centre randomised trial of an antidepressant for patients with advanced cancer (Stockler, O’Connoll, Nowack, Goldstein, Turner, Wilcken, Wyld, Abdi, Glasgow, Beale). This was the largest study of its kind ever conducted world-wide.
Another study explored the acceptability and effectiveness of a structured supervision experience for General Practitioners caring for terminally ill patients (Varghese, Kelly, Burnett, Kelly, Robertson, Mitchell, Turner, Treston).
3. Scholarship of research and translational research:
A major theme has been scholarship in research and collation of evidence into Clinical Practice Guidelines and implementation of these to guide health professionals in provision of optimal clinical care.
I have chaired working groups developing the following NHMRC-endorsed Clinical Practice Guidelines:
- Clinical Guidance for Responding to Suffering in Adults with Cancer (http://guidelines.canceraustralia.gov.au/guidelines/suffering/ch01.php)
- Clinical Practice Guidelines for the Psychosocial Care of Adults with Cancer
- Clinical Practice Guidelines for the Care of Younger Women with Breast Cancer
- Clinical Practice Guidelines for the Psychosocial Care of Women with Breast Cancer
- In addition I have been an active member of working groups which developed other NHMRC-endorsed guidelines: Clinical Practice Guidelines for the Management of Women with Early Breast Cancer, Clinical Practice Guidelines for the Management of Women with Advanced Breast Cancer, and consumer versions of these.
Chair of a working group convened by Cancer Australia to develop national Psychosocial Indicators as part of a National Cancer Control Indicators framework.
PROMPT study, a multi-site randomised controlled trial (Turner, Kelly, Clarke, Yates, Aranda, Jolley) aiming to demonstrate the effectiveness of psychosocial interventions delivered by novel service providers who have undergone focused training and receive ongoing supervision. The study demonstrated that a brief intervention was insufficient to improve depression in cancer patients. Patients with advanced disease experienced improvement in several practical areas of need.
Current RCT of a nurse-delivered survivorship intervention for patients who have completed treatment for head and neck cancer, based on promotion of self-efficacy and using models of chronic disease self-management
RCT of a manual-based therapy for patients with clinically significant fear of cancer recurrence. Recruitment has ceased and data is being analysed
The PROMPT study was an RCT of a health-professional delivered brief intervention for depressed cancer patients. The study demonstrated that a brief intervention was insufficient to improve depression. Patients with advanced disease experienced improvements in several practical domains
Development and evaluation of a structured educational initiative for onocology nurses. Nurses demonstrated increased knowledge and skills post-training.
Head, School of Nursing at Queensland University of Technology and Director for Queensland Health’s statewide Centre for Palliative Care Research and Education (CPCRE)
Distinguished Professor Yates is jointly appointed as Head, School of Nursing at Queensland University of Technology and Director for Queensland Health’s statewide Centre for Palliative Care Research and Education (CPCRE). She leads a range of research and service improvement programs focused on developing workforce capacity in cancer and palliative care, advancing the management of cancer related symptoms and treatment side effects, and strengthening the nexus between research, policy and practice in cancer care. Patsy has served as member of the Executive Committee of the Clinical Oncological Society of Australia and is currently President of Palliative Care Australia. She was a member of the Executive Committee for the International Society of Nurses in Cancer Care from 2004-2012. Patsy has also been a member of the Nursing and Midwifery Board of Queensland since 2008. She is regularly invited to provide expert advice to professional groups and government bodies, and has held ministerial appointments on a number of Boards and Committees for Federal and State Governments. Patsy has received awards in recognition of her research, teaching and service, including being awarded the Tom Reeve Oration Award for Outstanding Contribution to Cancer Care and Life Membership from the Cancer Nurses Society of Australia as well as the Clinical Oncological Society of Australia. In 2010, she was awarded a Citation from the Australian Learning and Teaching Council for Outstanding Contribution to Student Learning. Patsy is a fellow of the American Academy of Nursing and has recently been inducted into the Sigma Theta Tau International Nurse Researcher Hall of Fame.
2015-2017: The changing landscapes of survivorship: A sociological study of life with cancer. Australian Research Council Discovery Grant.
2014-2019: Chronic Kidney Disease Centre for Research Excellence. National Health and Medical Research Council.
2014-2015: Younger Women’s Wellness after Cancer Program: Pilot Study. Royal Brisbane and Women’s Hospital Research Foundation.
2014-2015: Pre-post determination of effect of oncogeriatric assessment and intervention on chemotherapy outcomes in solid cancer patients aged 70 years and over. PA Research Foundation.
2013-2018: Centre for Research Excellence in End of Life Care. National Health and Medical Research Council.
2013-2015: The Women’s Wellness after Cancer Program: a national multisite randomized clinical trial of an e-health enabled lifestyle modification intervention to improve the health and wellness of women after cancer treatment. National Health and Medical Research Council.
2013-2015: Finding My Way: A randomized controlled trial evaluating an internet self-help program for cancer-related distress. National Health and Medical Research Council.
2013-2015: Improving quality of life in high-risk cancer populations: a randomized trial of a structured intervention for head and neck cancer survivors. National Health and Medical Research Council.
2012-2015: Pathways to and through palliative care: a sociological study of patient, carer and clinician experiences at the end-of-life. Australian Research Council.
Industry Research Activities
2013-2015: National Advisory Service for Palliative Care and Advance Care Planning. Australian Government, Department of Health and Ageing.
2012-2014: Evaluation of the role of the Prostate Specialist Nurse: A National PCFA Pilot Project. Prostate Cancer Foundation of Australia.
2011-2014: National Coordination and Management of the Program of Experience in the Palliative Approach (Phase 4). Australian Government, Department of Health and Ageing.
2011-2014: Palliative Care Curriculum for Undergraduates (PCC4U). Australian Government, Department of Health and Ageing.
Patsy Yates’s full profile, contact information and publications are available on:
A/Prof Louisa Gordon
Team Head, Senior Research Fellow, Health Economics QIMR
I am a mid-career researcher with 15 years’ experience as a health economist and public health researcher. My research is focused on economic evaluation, economic modelling, statistical analysis of cost data, study design and research methods for health economics.
Over the past six years I have been chief investigator on competitive research grants totalling over $5 million from the NHMRC & ARC and on research consultancies totalling over $5.2 million including reports to decision-makers at the Department of Health. My research addresses the societal cost of health issues and the cost-effectiveness of health interventions and technologies.
In 2017, I was awarded $480,000, 18-months funding by the Queensland Genomic Health Alliance to lead the Evaluation of Clinical Genomics workstream capability. This involves building evaluation activities into four clinical demonstration projects which will implement genomic testing in various patient groups.
During the course of my research career I have worked on projects covering a wide range of health issues such as:
- behaviour change interventions during cancer survivorship
- genetic testing
- work loss following colorectal cancer
- the economics of ultraviolet radiation on health.
During this work, I collaborate widely with clinicians and health policymakers to facilitate translation of research outcomes and communicate to relevant stakeholders.
I welcome enquiries by students interested in undertaking cost-effectiveness or economic analyses in health care services.
Other current appointments
- Adjunct Associate Professor, School of Nursing, QUT.
- Adjunct Associate Professor, School of Medicine, UQ.
- Principal Research Fellow, Griffith University.
- NHMRC Post-doctoral Research Fellow, QIMR Berghofer.
- Health Economist , Cancer Council Queensland.
Current Area of Research
- Economic evaluation.
- Decision-analytic modelling.
- Cancer interventions.
- Pilot evaluation of the Nurse Navigator program in Queensland Health.
- Within-trial cost-effectiveness analysis of The ENHANCES study – Enhancing head and neck cancer patients’ experiences of survivorship.
- Within-trial cost-effectiveness analysis of a decision aid and DVD information support for men diagnosed with low-risk prostate cancer.
- Evaluation of clinical genomics projects in Queensland.
- Costs of Surviving Cancer – a Queensland study (COS-Q).
- Pilot evaluation of the transplant skin clinic project.
- Queensland Genomics Health Alliance CI Gordon LG, Co-investigators: Graves N, Webb P, Lakhani S, Griffiths L, Spurdle A, Waddell N, Schofield D, Shrestha R, Cunich M, Khurshid A, Tan O, Rynehart L, Lymer S, West S. Evaluation of Clinical Genomic Projects in Action in Queensland. 2017-2018, $480,000.
- Australian Red Cross Blood Service Gordon L. ‘Economic analysis of RHD genotyping to target pregnant women for antenatal and post-partum anti-D prophylaxis ($20,000).
- NHMRC Project Grant #1079720 – Schofield P, Chambers SK, Juraskona I, Gordon LG, Gardiner F. ‘ASTROID: Active Surveillance and other TReatment OptIons for prostate cancer. An RCT of decision aid and DVD information support for men diagnosed with low-risk prostate cancer.’ 2015-2018 ($749,704).
- NHMRC Project Grant #1041640 JTurner, Fraser A, McCarthy A, Gordon L Hughes B, Burmeister B, Thomson D, Skerman H, Carswell K, Basone M, Yates P, Chan R. Improving quality of life in high-risk cancer populations: a RCT of an intervention for head and neck cancer survivors. 2013-2015 ($476,074).
- NHMRC Project Grant #1029613 Flenady V, Gardener G, Wilson P, Cooke L, Gordon A, Ellwood D, Alison K, Charles A, Khong Y, Teale G, Morris J, Coory M, Gordon L, Thomas S, Dennis A, Jennings B, Sullivan E. Investigating causes of stillbirths: a prospective cohort study examining use and effectiveness of a comprehensive investigation protocol. Mater Medical Research Institute Ltd ($554,506).
Adj A/Prof Leanne Stone
Director of Nursing, Cancer Services, Princess Alexandra Hospital
In my current position, I provide a clinical cancer perspective to the development and expansion of Cancer Services across multiple facilities. My comprehensive cancer nursing career enables me to contribute a specialist cancer perspective to the planning of services, with the aim of achieving integrated key objectives from the Health Service Strategic Plan into related service delivery across the Clinical Stream and organisation. Awareness of the role and function of each discrete specialty within the complex mix of Cancer Services (such as radiation oncology, haematology, medical oncology, breast screen and palliative care) ensures representation and consultation across a broad range of meetings, committees and reference groups. My knowledge of the political environment, health service legislation, awards and contemporary cancer service standards of nursing practice is demonstrated through the success of the Cancer Service Stream meeting clinical service outcomes, and meeting on-going strategies to achieve, meet and sustain financial and clinical targets.
- APHRA Registration Number: NMW: 0001425505, with no restrictions, notations or conditions on practice.
- Registered Nurse and Midwife
- Cancer Credentialed Nurse
- Graduate Certificate of Cancer Nursing – Queensland University of Technology
- Graduate Diploma of Cancer Nursing – Queensland University of Technology
- Master of Nursing, Cancer Nursing – Queensland University of Technology
- Doctorate of Health Science (Candidate) – Queensland University of Technology
- Chemotherapy Certificate 2002 – King Faisal Specialist Hospital and Research Centre (KFSHRC) Jeddah, Saudi Arabia
- Leadership and Management Development Program 2002 (KFSHRC, Jeddah, Saudi Arabia)
- Nursing Leadership and Management Program 2006 (Queensland Health).
Dr Natalie Bradford
Senior Research Fellow, Queensland University of Technology
The consequences of cancer and treatment on fertility can be a continuing source of distress for adolescent and young adults. Oncofertility is a developing specialty that focuses on the reproductive future for cancer survivors as well as interventions to manage the psychosocial aspects of loss of reproductive function. This project aimed to identify the clinical practice of fertility preservation for young people aged 15-24 years across five tertiary cancer centres in Queensland. Data were examined over a five year period (2012-2016) regarding documented risk of infertility discussions, referral to fertility specialists and fertility preservation. Analysis identify variation in clinical practice associated with age, gender and disease type. While targeted interventions in 2015 were effective in reducing variations across some domains, the lack of uniform guidelines, clear referral pathways and limited consensus on the best way to deliver and provide services continue as barriers to equitable fertility preservation. We aim to develop further interventions to address these issues.
- The effects of bundled interventions on clinical practice for fertility preservation amongst young cancer patients