PREPARES: Patients and RElatives affected by PAncreatic cancer: Referral, Education and Support trial
People with pancreatic cancer have the worst prognosis of any cancer, with 50% of deaths occurring within five months of diagnosis. Our previous observational research indicates that pancreatic cancer patients and their carers have exceptionally high levels of unmet needs, and are more distressed than other cancer patients. PREPARES is a pilot intervention trial, in which families are offered up to 10 sessions of counselling delivered by a trained nurse via telehealth technology. The intervention is based on a self-efficacy paradigm and involves assessing needs, delivering intervention components appropriate to those needs, and providing feedback to clinicians where the nurse’s assessment is that further medical investigation and management may be warranted. The pilot trial will assess feasibility and acceptability of the intervention and will inform the development of a fully powered trial aimed to investigate the effects of the PREPARES intervention on distress, quality of life, supportive care needs, clinical factors (e.g. pain) and survival. For more information, please contact lead PI- Dr Vanessa Beesley.
QCCS Team Members
QCCS Co-Chair and Professor of Cancer Nursing
Doctor of Philosophy (Queensland University of Technology), Master of Applied Science (Research) (Queensland University of Technology), Bachelor of Nursing (Queensland University of Technology)
Dr Raymond Chan is Professor of Cancer Nursing, Princess Alexandra Hospital and Queensland University of Technology. To date, he has attracted over 8.5 million (AUD) of research project grants as a chief investigator (> $2 Million as CIA) to undertake research in supportive cancer care. Dr Chan is a chief investigator for 4 current/past NHMRC project grants and 1 NHMRC Fellowship, and has published 97 peer-reviewed articles. Ray is currently the Chair for the Survivorship Group, Multinational Association for Supportive Care in Cancer (MASCC), and the Board Director (Knowledge Development and Dissemination) for the International Society of Nurses in Cancer Care (ISNCC). He is a past President for the Cancer Nurses Society of Australia (CNSA), the peak professional body representing cancer nurses across Australia.
Recent funded project highlights include:
- (2019-2020): ImplEMenting a nurse-coordinated, INtegrated, shared-care model involving specialists and general practitioners in breast cancer post-treatmENT follow-up: a Phase II randomised controlled trial (The EMINENT Trial). Metro South Health (CIA)
- (2017-2020): A sequential multiple assignment randomised trial (SMART) of nursing interventions to reduce pain associated with chemotherapy induced peripheral neuropathy. NHMRC (CID)
- (2016-2019): Peripherally InSerted Central catheter Securement: the PISCES Trial. NHMRC (CIC)
- (2014-2017): Development and evaluation of a nurse-led, tailored self-management behavioural intervention for managing distressing symptoms in patients with advanced cancer (The SM2 Study). RBWH Foundation and NHMRC (CIA)
- (2014-2015): Younger women’s wellness after cancer program. RBWH Foundation (CID)
- (2014): Central venous Access device SeCurement And Dressing Effectiveness in Cancer Care: The CASCADE Trial. RBWH Foundation (CIA)
- (2013-2016): Improving quality of life in high-risk cancer populations: a randomised trial of a structured intervention for head and neck cancer survivors. NHMRC (CIJ)
- (2012-2013): A double-blind randomised controlled trial of Moogoo Udder Cream® versus aqueous cream for managing radiation-induced skin reactions in patients with cancer. RBWH Foundation; Office of Health and Medical Research; Cancer Nurses Society of Australia; Moogoo Skincare
- (2011-2014): The RSVP Trial: Replacement of Intravascular device administration sets after Standard Versus Prolonged use. NHMRC and RBWH Foundation (CIG)
- (2010): Self-management associated with fatigue in patients with advanced cancer. RBWH Foundation, Queensland Nursing Council, Royal College of Nursing Australia (CIA)
Recent QCCS Project
- The effects of bundled interventions on clinical practice for fertility preservation amongst young cancer patients
A/Prof David Wyld
Director, Department of Medical Oncology, RBWH
Qualifications: MBBS (Hons), University of Qld, 1987; RACP Advanced Training in Medical Oncology, 1996; Fellowship of Royal Australian College of Physicians (FRACP), 1996.
– Associate Professor, School of Medicine, University of Queensland (UQ)
– Adjunct Associate Professor, Faculty of Health, Queensland University of Technology (QUT)
– Affiliate, QIMR Berghofer Medical Research Institute
Assoc Prof Wyld is a Medical Oncologist who has practiced as a staff specialist (currently Eminent status) at Royal Brisbane and Women’s Hospital (RBWH) for over 20 years, after having undertaken an ICRF Cancer Research Fellowship in Leeds, UK, in 1996-97. He has been the Director of Medical Oncology at RBWH for 20 years, during which time he has overseen the development of the large, highly regarded Medical Oncology clinical trials unit at RBWH, and has managed the unit continuously for almost 20 years. Over the last 20 years as a full-time practicing cancer clinician at RBWH, Assoc Prof Wyld has maintained an active research focus, predominantly in the area of clinical research, including a major focus on clinical trials (see below). Assoc Prof Wyld’s research involvement over 20 years has been broad, but with a particular focus on gastrointestinal cancers, gynaecologic malignancies and qualitative patient-focused research. His current major research interests are in the area of neuroendocrine tumours (NETs), pancreatic cancer, colorectal cancer and the area of supportive care, survivorship and qualitative patient focused research. He also has a long history of mentoring staff in clinical research and a proven track record of research collaboration.
Prof Monika Janda
Professor in Behavioural Science, Centre for Health Services Research, Faculty of Medicine, University of Queensland
Ph.d (University of Vienna), Master of Philosophy (University of Vienna)
Prof Monika Janda is a behavioural scientist with 15 years of experience in cancer research. She has over 180 publications in peer-reviewed journals and has presented her work at national and international conferences. Monika is currently involved in epidemiological and behavioural research to address the public health impact of
- breast cancer
- endometrial cancer
- ovarian cancer
- brain tumours.
Awards NHMRC Career Development Award level 2 2013-2016 NHMRC Career Development Award level 1 2009-2012 VC Award of Research excellence 2013
- Epidemiological and behavioural oncology research to address the public health impact of cancer
- Quality of Life Research
Professional memberships and associations
- Member – Prevention Committee, International Psycho-Oncology Society
- Member – Scientific Advisory Committee Psycho-Oncology Co-operative Research Group http://www.pocog.org.au (past chair 2013-16)
- Past member – National Working Group for Gynaecological Cancer/Cancer Australia
- Past member – Scientific Advisory Committee Cooperative Trial Group for Neuro-oncology (COGNO)
- Australian Society for Medical Research (ASMR)
- Australian Psychological Society (College of Health Psychologists)
Monika’s publications are available on:
Prof Jane Turner
Professor of Medicine (Psychiatry) Psycho-Oncologist, UQ
- Doctor of Philosophy, The University of Queensland
- FRANZCP, Royal Australian and New Zealand College of Psychiatrists
- MBBS, The University of Queensland
I have worked for over 20 years in the field of Psycho-Oncology as a psychiatrist providing treatment for patients with cancer and their families, and developing a program of research focused on interventions in areas of clinical need, and translational research examining sustainable models of service delivery.
Psycho-Oncology encompasses attention to the psychological, emotional and social needs of people with cancer and their families or carers. It encompasses attention to spiritual and cultural concerns, across all phases of the cancer experience from diagnosis, through treatment, survivorship or advanced diseases. It is a relatively new discipline. The International Psycho-Oncology Society was established in 1984. As such, much of the research in this field has been descriptive and it is only in recent years that robust trials of interventions have become more common. involves attention to the psychological, emotional and social needs of people with cancer and their family or carers. ath.
My research in Psycho-Oncology relates to three core themes which draw on both my clinical and educational expertise:
1. Promotion of wellness following completion of active cancer treatment:
Current RCTs are:
- Improving quality of life in high-risk cancer populations: a randomised trial of a structured intervention for head and neck cancer survivors (Turner, Yates, Kenny, Gordon, Burmeister, Thomson, Hughes, McCarthy, Perry, Chan)
- The women’s wellness after cancer program: a national multisite RCT of an E-Health enabled lifestyle modification intervention to improve the health and wellness of women after cancer treatment (Anderson, McCarthy, Yates, Turner, Monterosso, Krishnasamy, White, Hall, Tjondronegoro)
- Evaluation of a psychological and educational intervention for fear of cancer recurrence: A clustered randomised controlled trial (Butow, Thewes, Turner, Gilchrist, Beith, Girgis, Sharpe, Bell, Mihalopoulos).
- Coping Together: A randomised controlled trial of a self-directed coping skills intervention for patients with cancer and their partners (Girgis, Lambert, Turner, McElduff, Kayser, Mihalopoulos).
- Finding My Way: A randomised controlled trial evaluating an internet self-help program for cancer-related distress (Beatty, Koczwara, Wade, Turner, Butow, Knott, Lambert, Milne, Wootten, De Bono, Katris)
Completed studies include: i) a pilot study of an exercise intervention for women after completion of chemotherapy for breast cancer (Turner, Hayes, Reul-Hirche); ii) RCT of exercise in women with Lymphoedema secondary to treatment for breast cancer (Hayes, Reul-Hirche, Turner), iii) RCT examining promotion of wellness through cancer helplines (Chambers, Occhipinti, Turner, Carter, Dunn).
2. The emotional dimensions of cancer for patients and dependent children:
Initial work exploring the emotional impact of the diagnosis of advanced breast cancer (Turner, Kelly, Swanson, Allison, Wetzig) identified key areas of unmet need relating to concerns of parents and their response to their children.
This provided the impetus for a pilot study in which an educational intervention was developed to enhance the capacity of oncology nurses to provide supportive care for parents with advanced cancer (Turner, Clavarino, Butow, Yates, Hargraves, O’Connor, Hausmann).
Collaborations in the area of advanced cancer include a multi-centre randomised trial of an antidepressant for patients with advanced cancer (Stockler, O’Connoll, Nowack, Goldstein, Turner, Wilcken, Wyld, Abdi, Glasgow, Beale). This was the largest study of its kind ever conducted world-wide.
Another study explored the acceptability and effectiveness of a structured supervision experience for General Practitioners caring for terminally ill patients (Varghese, Kelly, Burnett, Kelly, Robertson, Mitchell, Turner, Treston).
3. Scholarship of research and translational research:
A major theme has been scholarship in research and collation of evidence into Clinical Practice Guidelines and implementation of these to guide health professionals in provision of optimal clinical care.
I have chaired working groups developing the following NHMRC-endorsed Clinical Practice Guidelines:
- Clinical Guidance for Responding to Suffering in Adults with Cancer (http://guidelines.canceraustralia.gov.au/guidelines/suffering/ch01.php)
- Clinical Practice Guidelines for the Psychosocial Care of Adults with Cancer
- Clinical Practice Guidelines for the Care of Younger Women with Breast Cancer
- Clinical Practice Guidelines for the Psychosocial Care of Women with Breast Cancer
- In addition I have been an active member of working groups which developed other NHMRC-endorsed guidelines: Clinical Practice Guidelines for the Management of Women with Early Breast Cancer, Clinical Practice Guidelines for the Management of Women with Advanced Breast Cancer, and consumer versions of these.
Chair of a working group convened by Cancer Australia to develop national Psychosocial Indicators as part of a National Cancer Control Indicators framework.
PROMPT study, a multi-site randomised controlled trial (Turner, Kelly, Clarke, Yates, Aranda, Jolley) aiming to demonstrate the effectiveness of psychosocial interventions delivered by novel service providers who have undergone focused training and receive ongoing supervision. The study demonstrated that a brief intervention was insufficient to improve depression in cancer patients. Patients with advanced disease experienced improvement in several practical areas of need.
Current RCT of a nurse-delivered survivorship intervention for patients who have completed treatment for head and neck cancer, based on promotion of self-efficacy and using models of chronic disease self-management
RCT of a manual-based therapy for patients with clinically significant fear of cancer recurrence. Recruitment has ceased and data is being analysed
The PROMPT study was an RCT of a health-professional delivered brief intervention for depressed cancer patients. The study demonstrated that a brief intervention was insufficient to improve depression. Patients with advanced disease experienced improvements in several practical domains
Development and evaluation of a structured educational initiative for onocology nurses. Nurses demonstrated increased knowledge and skills post-training.
Head, School of Nursing at Queensland University of Technology and Director for Queensland Health’s statewide Centre for Palliative Care Research and Education (CPCRE)
Distinguished Professor Yates is jointly appointed as Head, School of Nursing at Queensland University of Technology and Director for Queensland Health’s statewide Centre for Palliative Care Research and Education (CPCRE). She leads a range of research and service improvement programs focused on developing workforce capacity in cancer and palliative care, advancing the management of cancer related symptoms and treatment side effects, and strengthening the nexus between research, policy and practice in cancer care. Patsy has served as member of the Executive Committee of the Clinical Oncological Society of Australia and is currently President of Palliative Care Australia. She was a member of the Executive Committee for the International Society of Nurses in Cancer Care from 2004-2012. Patsy has also been a member of the Nursing and Midwifery Board of Queensland since 2008. She is regularly invited to provide expert advice to professional groups and government bodies, and has held ministerial appointments on a number of Boards and Committees for Federal and State Governments. Patsy has received awards in recognition of her research, teaching and service, including being awarded the Tom Reeve Oration Award for Outstanding Contribution to Cancer Care and Life Membership from the Cancer Nurses Society of Australia as well as the Clinical Oncological Society of Australia. In 2010, she was awarded a Citation from the Australian Learning and Teaching Council for Outstanding Contribution to Student Learning. Patsy is a fellow of the American Academy of Nursing and has recently been inducted into the Sigma Theta Tau International Nurse Researcher Hall of Fame.
2015-2017: The changing landscapes of survivorship: A sociological study of life with cancer. Australian Research Council Discovery Grant.
2014-2019: Chronic Kidney Disease Centre for Research Excellence. National Health and Medical Research Council.
2014-2015: Younger Women’s Wellness after Cancer Program: Pilot Study. Royal Brisbane and Women’s Hospital Research Foundation.
2014-2015: Pre-post determination of effect of oncogeriatric assessment and intervention on chemotherapy outcomes in solid cancer patients aged 70 years and over. PA Research Foundation.
2013-2018: Centre for Research Excellence in End of Life Care. National Health and Medical Research Council.
2013-2015: The Women’s Wellness after Cancer Program: a national multisite randomized clinical trial of an e-health enabled lifestyle modification intervention to improve the health and wellness of women after cancer treatment. National Health and Medical Research Council.
2013-2015: Finding My Way: A randomized controlled trial evaluating an internet self-help program for cancer-related distress. National Health and Medical Research Council.
2013-2015: Improving quality of life in high-risk cancer populations: a randomized trial of a structured intervention for head and neck cancer survivors. National Health and Medical Research Council.
2012-2015: Pathways to and through palliative care: a sociological study of patient, carer and clinician experiences at the end-of-life. Australian Research Council.
Industry Research Activities
2013-2015: National Advisory Service for Palliative Care and Advance Care Planning. Australian Government, Department of Health and Ageing.
2012-2014: Evaluation of the role of the Prostate Specialist Nurse: A National PCFA Pilot Project. Prostate Cancer Foundation of Australia.
2011-2014: National Coordination and Management of the Program of Experience in the Palliative Approach (Phase 4). Australian Government, Department of Health and Ageing.
2011-2014: Palliative Care Curriculum for Undergraduates (PCC4U). Australian Government, Department of Health and Ageing.
Patsy Yates’s full profile, contact information and publications are available on:
Adj A/Prof Vanessa Beesley
Senior Research Officer, QIMR
I am a behavioral epidemiologist who specialises in the study of patient-reported outcomes’ in cancer research. Patient-centred care is now recognised as the benchmark of quality care for people affected by cancer and I have dedicated the past decade and a half to working in this field. I am regarded as a leading expert, as demonstrated by: (1) being the recipient of two Cancer Australia contracts to provide recommendations to government about how to improve the care of people affected by cancer; and (2) success as a chief investigator of six patient-reported outcome studies funded through major national schemes or specialist agencies. I have substantive expertise in analysis of patient-reported outcome data and have co-written a manual on this topic for staff at QIMR Berghofer. I have had significant career disruptions for maternity/carers leave such that since 2012 I have worked only 2.5 years full time equivalent (FTE). However, since 2012, I have publish 30 peer-reviewed journal articles (10 as first author and 2 as last/senior author).
- PREPARES: Patients and RElatives affected by PAncreatic cancer: Referral, Education and Support trial
A/Prof Louisa Gordon
Team Head, Senior Research Fellow, Health Economics QIMR
I am a mid-career researcher with 15 years’ experience as a health economist and public health researcher. My research is focused on economic evaluation, economic modelling, statistical analysis of cost data, study design and research methods for health economics.
Over the past six years I have been chief investigator on competitive research grants totalling over $5 million from the NHMRC & ARC and on research consultancies totalling over $5.2 million including reports to decision-makers at the Department of Health. My research addresses the societal cost of health issues and the cost-effectiveness of health interventions and technologies.
In 2017, I was awarded $480,000, 18-months funding by the Queensland Genomic Health Alliance to lead the Evaluation of Clinical Genomics workstream capability. This involves building evaluation activities into four clinical demonstration projects which will implement genomic testing in various patient groups.
During the course of my research career I have worked on projects covering a wide range of health issues such as:
- behaviour change interventions during cancer survivorship
- genetic testing
- work loss following colorectal cancer
- the economics of ultraviolet radiation on health.
During this work, I collaborate widely with clinicians and health policymakers to facilitate translation of research outcomes and communicate to relevant stakeholders.
I welcome enquiries by students interested in undertaking cost-effectiveness or economic analyses in health care services.
Other current appointments
- Adjunct Associate Professor, School of Nursing, QUT.
- Adjunct Associate Professor, School of Medicine, UQ.
- Principal Research Fellow, Griffith University.
- NHMRC Post-doctoral Research Fellow, QIMR Berghofer.
- Health Economist , Cancer Council Queensland.
Current Area of Research
- Economic evaluation.
- Decision-analytic modelling.
- Cancer interventions.
- Pilot evaluation of the Nurse Navigator program in Queensland Health.
- Within-trial cost-effectiveness analysis of The ENHANCES study – Enhancing head and neck cancer patients’ experiences of survivorship.
- Within-trial cost-effectiveness analysis of a decision aid and DVD information support for men diagnosed with low-risk prostate cancer.
- Evaluation of clinical genomics projects in Queensland.
- Costs of Surviving Cancer – a Queensland study (COS-Q).
- Pilot evaluation of the transplant skin clinic project.
- Queensland Genomics Health Alliance CI Gordon LG, Co-investigators: Graves N, Webb P, Lakhani S, Griffiths L, Spurdle A, Waddell N, Schofield D, Shrestha R, Cunich M, Khurshid A, Tan O, Rynehart L, Lymer S, West S. Evaluation of Clinical Genomic Projects in Action in Queensland. 2017-2018, $480,000.
- Australian Red Cross Blood Service Gordon L. ‘Economic analysis of RHD genotyping to target pregnant women for antenatal and post-partum anti-D prophylaxis ($20,000).
- NHMRC Project Grant #1079720 – Schofield P, Chambers SK, Juraskona I, Gordon LG, Gardiner F. ‘ASTROID: Active Surveillance and other TReatment OptIons for prostate cancer. An RCT of decision aid and DVD information support for men diagnosed with low-risk prostate cancer.’ 2015-2018 ($749,704).
- NHMRC Project Grant #1041640 JTurner, Fraser A, McCarthy A, Gordon L Hughes B, Burmeister B, Thomson D, Skerman H, Carswell K, Basone M, Yates P, Chan R. Improving quality of life in high-risk cancer populations: a RCT of an intervention for head and neck cancer survivors. 2013-2015 ($476,074).
- NHMRC Project Grant #1029613 Flenady V, Gardener G, Wilson P, Cooke L, Gordon A, Ellwood D, Alison K, Charles A, Khong Y, Teale G, Morris J, Coory M, Gordon L, Thomas S, Dennis A, Jennings B, Sullivan E. Investigating causes of stillbirths: a prospective cohort study examining use and effectiveness of a comprehensive investigation protocol. Mater Medical Research Institute Ltd ($554,506).